工程功能粒子调节T细胞反应
Yudong Li1, Shukun Li1,2, Jari F Scheerstra1
1Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
概括
工程颗粒生物材料正在推进基于T细胞的免疫调节以治疗疾病. 这些功能粒子有助于调节免疫治疗中的T细胞反应,包括采用T细胞治疗和免疫检查点治疗.
科学领域:
- 生物材料科学 生物材料科学
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
- 治疗工程 治疗工程
背景情况:
- T细胞对适应性免疫非常重要,与其他免疫细胞合作,对抗感染和癌症.
- 不调节的T细胞反应可能导致自身免疫性疾病,需要外部调节.
- 目前的免疫疗法通常需要对T细胞进行外部工程,以提高其有效性.
研究的目的:
- 审查使用颗粒生物材料的基于T细胞的免疫调节的原则和发展.
- 为调节T细胞特征的功能粒子平台概述关键设计考虑因素.
- 讨论采用T细胞疗法,免疫检查点疗法和恢复免疫耐受性的治疗应用.
主要方法:
- 具有T细胞识别和激活信号的纳米到微米尺寸颗粒生物材料的工程.
- 使用粒子作为载体,以有针对性和受控地输送治疗性货物 (药物,细胞因子,抗体).
- 设计用于in vivo重编程或抑制过度活跃的T细胞的粒子.
主要成果:
- 模仿抗原呈现细胞的微粒体已经在T细胞扩张中取得了成功,用于采用T细胞疗法.
- 颗粒辅助输送系统可以定制药物输送,提高生物可用性和降低毒性.
- 功能性颗粒通过调节异常T细胞活性来恢复免疫耐受性的潜力.
结论:
- 功能性颗粒生物材料对于推进基于T细胞的免疫疗法至关重要.
- 颗粒平台的战略设计允许精确调节T细胞反应.
- 对粒子工程的进一步研究有望用于治疗癌症,传染病和自身免疫性疾病.
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