在轴突,树突,突触和超越的RNA
Richard Taylor1, Nikolas Nikolaou2
1Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Frontiers in molecular neuroscience
|October 3, 2024
概括
神经元利用轴突和树突中的局部RNA进行快速反应. 本综述探讨了RNA多样性,功能和神经元通信中的外体的作用,并从先进的测序中获得未来的见解.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 编码和非编码RNA存在于神经元轴突,树突和突触中.
- 这些局部RNAs支持神经元的基本功能,如生长,分支,突触形成和可塑性.
研究的目的:
- 审查神经元亚细胞区内RNA子类的多样性.
- 讨论轴突,树突和突触局部转录组的相似之处和差异.
- 探索局部RNA的功能和命运以及它们在外基因组中的作用.
主要方法:
- 关于神经元RNA局部化的当前研究的文献综述.
- 对轴突,树突和突触转录组的现有数据的分析.
- 讨论新兴的第三代测序技术.
主要成果:
- 在神经元区中存在着RNA子类的显著多样性.
- 在轴突,树突和突触转录体中观察到不同的和重叠的RNA配置文件.
- 从神经细胞中芽的外体内含有RNA,对细胞间通信有影响.
结论:
- 局部RNA对神经元功能和可塑性至关重要.
- 了解局部转录组为神经元复杂性提供了洞察力.
- 先进的测序将揭示RNA异型和修饰的更多多样性.
相关概念视频
Neuron Structure
12.7K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
12.7K
The Synapse
124.4K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
124.4K
Neurons: The Axon
3.3K
Axons are long, cytoplasmic processes of nerve cells capable of propagating electrical impulses known as action potentials. The cytoplasm or axoplasm of an axon contains neurofibrils, neurotubules, small vesicles, lysosomes, mitochondria, and various enzymes, all encased within the axolemma, the plasma membrane of the axon.
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment....
3.3K
Neurons: The Cell Body and the Dendrites
2.7K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
2.7K
Neurons as Communicators of the Brain
1.1K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
Cell Body
The cell body, also known...
1.1K
Synaptic Signaling
5.5K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.5K


