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血液中的早期B淋巴细胞子集预测了败血症的预后
Yingqian Sun1, Yan Lu1, Xinling Pan2
1Clinical Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China.
Frontiers in immunology
|October 3, 2024
概括
在败血症预后中,B细胞子集至关重要. 过渡性 (Tr) B细胞减少和双阴性 (DN) B细胞增加表明结果不佳,有助于死亡率预测.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
背景情况:
- B 淋巴细胞在免疫调节和免疫抑制中发挥着至关重要的作用.
- B细胞子集的失调与各种疾病状态有关,包括败血症.
研究的目的:
- 为了研究患有败血症的患者外围B细胞子集的预后价值.
- 为了确定B细胞子集分析是否可以预测败血症死亡率.
主要方法:
- 周围血液B细胞子集在入院后的第1天和第7天在败血症患者和健康对照中使用流动细胞计分析.
- 根据28天的预后,患者被分为幸存者和非幸存者.
- 统计分析包括配对样本等级和试验,多变量考克斯回归,卡普兰-梅尔生存分析和ROC曲线分析.
主要成果:
- 败血症患者表现出异常的B细胞子集分布,并观察到选择性枯竭.
- 不幸存者在第一天显示过渡性 (Tr) B细胞和CD5+B细胞的比例/数量明显较低,双阴性 (DN) B细胞的比例较高.
- 在第一天增加的DN B细胞比例预测死亡率 (HR=1.092),B细胞子集参数提高了APACHE II得分的预后值 (AUC=0.840).
结论:
- B,Tr和CD5+B细胞的缺陷,以及持续升高的DN B细胞,与败血症预后不佳有关.
- B细胞子集对与败血症相关的死亡率具有显著的预测价值.
- 这些发现提供了关于B细胞在败血症中的作用的见解,以及改善患者管理和预测结果的潜在途径.
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