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在心脏移植接收者COVID-19感染后发生的Eosinophilic Endomyocarditis
Sara S Inglis1, Anshul R Gupta2, Francisco B Alexandrino1
1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
JACC. Case reports
|October 3, 2024
概括
乙性心肌炎 (EM) 是心力衰竭的一个罕见原因. 这一案例突显了COVID-19感染后心脏移植接受者的EM,强调了罕见的关联和治疗策略.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 乙性心肌炎 (EM) 是一种罕见的疾病,导致心力衰竭,往往具有严重的后果.
- 虽然在COVID-19疫苗接种后报告了EM,但其与活跃的SARS-CoV-2感染的关联是罕见的.
- 心脏移植接受者在管理心脏并发症方面面临着独特的挑战.
研究的目的:
- 报告心脏移植接受者在活跃的COVID-19感染后出现的第一个eosinophilic心肌炎病例.
- 讨论这种罕见的协会的临床表现,管理和结果.
- 突出潜在的治疗策略来管理EM在这个特定的患者群体.
主要方法:
- 一个61岁的女性心脏移植接受者的案例报告.
- 基于临床表现的EM诊断,并可能得到进一步调查的支持 (摘要中没有详细说明).
- 治疗包括内的支持,皮质类固醇和mepolizumab,用于治疗外围异敏的复发.
主要成果:
- 患者在感染COVID-19后,患上了EM的次要急性心力衰竭.
- 最初的治疗显示出部分反应,但发生了复发,出现了新的外围好色素.
- 随后的治疗,包括mepolizumab,导致了积极的反应.
结论:
- 这一病例代表了心脏移植接受者与活跃的SARS-CoV-2感染相关的第一个被记录的eosinophilic心肌炎病例.
- 这些发现强调了在COVID-19期间心力衰竭和宪法症状的心脏移植患者考虑EM的重要性.
- 在这种情况下,梅波利祖马布可能是管理复发性EM的有价值的治疗选择.
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