基于机器学习的现象组和功能性胃肠道疾病患者的预测模型,以揭示与气体生产相关的不同疾病子集
Lingling Zhu1,2, Shuo Xu3, Huaizhu Guo1,2
1Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Journal of translational internal medicine
|October 3, 2024
概括
机器学习通过整合症状和呼吸测试来识别功能性胃肠道疾病 (FGID) 的不同亚组. 这种方法有助于识别过度生产天然气的FGID,以便更好地做出处理决策.
科学领域:
- 胃肠病学 胃肠病学
- 医疗信息学 医疗信息学
- 微生物组研究 微生物组研究
背景情况:
- 功能性胃肠道疾病 (FGIDs) 的基于症状的分类在揭示潜在机制和指导治疗方面存在局限性.
- 小肠失生症被怀疑是FGID发展的原因之一.
- 需要新的方法来根据病理生理学来分类FGID.
研究的目的:
- 调查机器学习 (ML) 算法是否可以通过将胃肠道 (GI) 症状数据与乳糖呼吸测试结果集成来创建不同的患者群.
- 开发和验证基于ML的预测模型,用于识别FGID患者的过度气体产生.
主要方法:
- 一个有胃肠道症状的508名患者的前性队列接受了乳糖甲和硫化呼吸测试.
- 一个无监督的ML算法 (K-means集群) 整合了胃肠道症状和呼吸测试数据来对患者进行分类.
- 通用估计方程 (GEE) 模型分析了集群和呼吸气体概况之间的纵向关联. 开发并验证了过度气体生产的ML预测模型.
主要成果:
- 通过K-means集群,确定了4个不同的FGID患者集群.
- 集群2,3,4与腹部膨胀,腹和高气体产生有关,而集群1显示下腹部不适,心理抱怨和低气体产生.
- GEE模型证实了跨集群的时间变化的呼吸气体度. ML预测模型在识别过度天然气生产方面表现出很好的准确性.
结论:
- 基于ML的现象组提供了一个强大的方法来创建独特的FGID子集.
- 这些ML方法可以有效地识别FGID子集,其特点是气体产量增加,改善临床决策和治疗指导.
相关概念视频
01:20Gastrointestinal Motility Disorders
1.6K
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.6K
01:17Assessment of the Gastrointestinal System I: Subjective Data
855
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
855
01:29Assessment of the Gastrointestinal System II: Health Perception Pattern
636
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
636
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
1.0K
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
1.0K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
01:26Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
663
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
663