微流体抗溶剂结晶用于奇拉对称性破坏
Jiye Jang1, Gerard Coquerel2, Tae Seok Seo1
1Department of Chemical Engineering (BK21 FOUR Integrated Engineering Program), College of Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea. seots@khu.ac.kr.
Lab on a chip
|October 3, 2024
概括
微流体抗溶剂结晶揭示了临界溶液体积的影响,在酸晶体中破坏了奇拉对称性. 较小的体积促进单个反体的形成,而较大的体积增加了两个反体的可能性.
科学领域:
- 结晶科学 结晶科学
- 物理化学 物理化学
- 材料科学 材料科学 材料科学
背景情况:
- 状对称破裂 (CSB) 是晶体形成的一个基本现象.
- 在化过程中控制CSB对于生产纯化化合物至关重要.
- 传统的方法往往缺乏对结晶条件的精确控制.
研究的目的:
- 为了研究溶液体积对酸晶体中奇拉对称性破坏 (CSB) 的影响.
- 探索微流体抗溶剂结晶的使用,以控制性结晶.
- 确定乳液滴量与CSB结果之间的关系.
主要方法:
- 使用微流体装置在多德干中产生化溶液的均乳液滴.
- 采用一种通过将乙醇引入连续相的抗溶剂结晶方法.
- 在单个乳液滴中量化分析和可视化结晶.
主要成果:
- 在特定的临界乳液体积内观察到100%的奇拉对称性破坏 (CSB).
- 发现超过这个临界体积会增加两种反体形成的概率.
- 证明了溶液体积和CSB的程度之间的直接相关性.
结论:
- 溶液体积是一个关键参数,影响酸结晶过程中的奇拉对称性破裂.
- 微流体抗溶剂结晶可以精确控制CSB现象.
- 观察到的体积依赖性归因于快速的分子耗尽和超出临界体积的抑制初级核形成.
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