青春期开始的代谢编程
Clinton Roddick1, Mark Harris1, Paul L Hofman2
1Department of Endocrinology and Diabetes, Queensland Children's Hospital, Brisbane, Queensland, Australia.
Clinical endocrinology
|October 3, 2024
概括
母亲因素,如营养和内分泌干扰物,可以通过影响代谢信号来触发早期青春期. 这可能会增加后代代谢综合征的风险,可能会影响后代.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 发育生物学是发展生物学.
- 环境健康 环境健康
背景情况:
- 孕产妇的营养 (营养不足/营养过多) 和糖尿病与早期青春期发作有关.
- 产前暴露于内分泌干扰化学物质 (EDC) 与早期青春期有关.
- 青春期早期的儿童在青春期和年轻成人时期面临代谢综合征的风险增加.
研究的目的:
- 审查产前环境在规划青春期开始中的作用.
- 检查产前代谢压力因素对青春期平均年龄下降的影响.
主要方法:
- 进行了全面的文献审查.
- 通过PubMed搜索确定了相关的研究.
主要成果:
- 在kisspeptin-神经氧化物-激素释放激素 (KiNG) 轴上的代谢信号 (素,胰岛素) 介导着早期青春期.
- 产前暴露会增加后代患儿童肥胖,高胰岛素血和高血的风险.
- 这些代谢变化有助于更早地达到青春期的"值".
结论:
- 产前环境显著影响青春期的时间.
- 由于代谢编程的早期青春期发作可能会增加长期的健康风险.
- 干预措施可能有助于缓解这些编程效应的代际放大.
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