相关实验视频
Updated: Jun 10, 2026

09:19
Recombinant Retroviral Production and Infection of B Cells
Published on: February 19, 2011
2024年帕尔沃病毒B19反弹爆发以及对血液和血产品安全性的影响
Maria R Farcet1, Michael Karbiener1, Claudia Aberham2
1Global Pathogen Safety, Takeda Manufacturing Austria AG, Vienna, Austria.
Transfusion
|October 3, 2024
概括
人类帕维病毒B19 (B19V) 感染在2024年在欧洲激增,与大流行时代的差距有关. 数以百万计的血捐献的核酸检测显示B19V发病率增加,特别是在年轻的捐献者中.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 输血医学 输血医学
背景情况:
- 几个欧洲国家报告说,从2024年初开始,人类帕维病毒B19 (B19V) 感染的数量显著增加.
- 这种B19V发病率的增加引发了人们对输血中使用的血液制品安全性的担忧.
- 有限的大规模数据可用于分析这一特定的疫情爆发.
研究的目的:
- 分析欧洲和美国的血捐献中B19V的发病率.
- 评估B19V在最近爆发期间的流行病学趋势.
- 为血液捐献中关于B19V的风险评估提供数据.
主要方法:
- 对B19V进行核酸测试 (NAT) 是对个体血捐赠进行的.
- 数据收集时间为2018年6月至2024年5月.
- 捐款主要来自中欧国家 (9,600万) 和美国 (7070万).
主要成果:
- 与COVID-19前水平相比,中欧在2023年11月至2024年4月的B19V发病率增加了33倍.
- 美国也出现了类似的趋势,但同期的增长幅度低6倍.
- 最年轻的血捐赠者队列在B19V阳性方面表现出最显著的增长.
结论:
- 在COVID-19大流行期间的B19V感染差距是2023/2024爆发的可能原因,特别是在欧洲.
- 对血捐献的大规模B19V NAT提供了宝贵的流行病学见解,并支持对血液安全的风险评估.
- 考虑B19V NAT输血给高风险接受者或基于血清阳性的供体选择可能是合理的.
相关概念视频
Viral Recombination
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