综合性肺功能分析确定了1岁左右的前早产婴儿中占主导地位的阻塞性表型
Elkie S Stein1, Avigdor Hevroni2,3, Mor Zarfati2
1Department of Neonatology, Hadassah Medical Center, Jerusalem, Israel.
Pediatric pulmonology
|October 3, 2024
概括
过早出生的婴儿在第一年表现出严重的气道阻塞和肺功能不佳,往往对支气管扩展剂没有反应. 婴儿肺功能测试 (iPFT) 可以评估这种肺病.
科学领域:
- 儿科肺病学 儿科肺病学
- 新生儿科学 新生儿科学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 过早出生的婴儿在生命早期会出现严重的呼吸系统问题,其潜在原因尚未完全理解.
- 婴儿肺功能测试 (iPFT) 提供了一种方法来全面评估这一群体的肺功能.
研究的目的:
- 用全面的 iPFT 来表征早产婴儿的肺功能.
- 为了比较早产婴儿和早产婴儿之间的肺功能.
- 探索支气管肺疾病 (BPD) 和妊娠年龄 (GA) 对早产婴儿肺功能的影响.
主要方法:
- 在2008-2019年期间招募了150名婴儿 (104名早产婴儿,46名孕期对照婴儿).
- 对所有参与者进行了全婴儿肺功能测试 (iPFT).
- 进行了子分析,根据BPD状态和妊娠年龄 (GA) 进行了早产婴儿的比较.
主要成果:
- 与满期婴儿相比,早产婴儿表现出空气流量受损,肺部服从性降低和空气捕获.
- 只有15%的早产婴儿有正常的IPFT结果,而69%的晚产婴儿则是正常的.
- 在早产婴儿中,阻塞性模式占主导地位,其中72%对支气管扩展剂没有反应;功能残留容量的最大流量减少 (V'maxFRC) 与较低的出生体重和GA相关.
结论:
- 在早产婴儿在生命的第一年内,阻塞性,支气管扩展剂不响应的呼吸道疾病的高患病率是明显的.
- 支气管肺部疾病 (BPD) 状态并没有显著改变肺功能障碍的程度.
- 这些发现表明,在现代早产相关的肺病中,呼吸道为中心的病理存在,强调了早期肺功能查和V'maxFRC评估的实用性.
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