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Updated: May 5, 2026

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
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使用-交换质谱法对阿波利波蛋白E4的形态异质性进行定量评估

Subhrajyoti Dolai1, Sudip Pal1, S Deepa1

  • 1Tata Institute of Fundamental Research, 36/P, Gopanpally Village, Serilingampally Mandal, Hyderabad 500046, India.

The journal of physical chemistry. B
|October 3, 2024
PubMed
概括

阿波利波蛋白E4 (apoE4) 呈现出比apoE3更大的形状异质性,这是阿尔茨海默病风险的关键因素. -交换质谱法 (HDX-MS) 揭示了这些结构差异,为治疗药物开发提供了新的途径.

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