自闭症谱系障碍中的生物标志物和途径:基于蛋白质和代谢数据的单个元分析
1Department of Medical Statistics, School of Public Health, Sun Yat-sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou, 510080, Guangdong Province, P. R. China.
European archives of psychiatry and clinical neuroscience
|October 3, 2024
概括
这项研究在各种样本类型中确定了共享的蛋白质和代谢生物标志物,用于自闭症谱系障碍 (ASD) 诊断. 这些发现突出了ASD管理的潜在诊断工具.
科学领域:
- 生物标志物 生物标志物
- 神经科学是一个神经科学.
- 基因组学就是基因组学.
背景情况:
- 自闭症谱系障碍 (ASD) 诊断和管理缺乏确定的生物标志物.
- 蛋白质组学和代谢学为识别关键ASD生物标志物和生物通路提供了潜力.
研究的目的:
- 进行元分析,比较ASD生物标志物在中枢神经系统,循环和非侵入性样本中的一致性.
- 确定与ASD相关的丰富生物通路.
主要方法:
- 对926个蛋白质组学和619个代谢组学文章的单独元分析.
- 从10项研究 (940种不同的蛋白质) 和16项研究 (748种不同的代谢物) 收集数据.
- 进行了路径丰富分析.
主要成果:
- 在不同样本类型中确定了共享的蛋白质标记物 (FLOT2,ApoE,EHD3,VCL,GSN,MDH2) 和代谢标记物 (希普酸,酸).
- 糖解/葡萄糖生成,碳代谢和谷氨代谢途径在ASD中得到丰富.
- 在中枢神经系统,循环和非侵入性样本中发现了6种共享蛋白质和2种代谢标记物.
结论:
- 在多种样本类型中共享的生物标志物对ASD诊断和管理具有重大潜力.
- 需要进一步的研究来验证这些已识别的生物标志物在自闭症谱系障碍中的临床应用.
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