自行纳米乳化药物输送系统用于雾化:制造和评估用于系统输送阿托瓦斯塔丁
Muhammad Danish Saeed1, Kifayat Ullah Shah2, Muhammad Fahad3
1Particle Design and Drug Delivery Laboratory, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, 29050, Khyber Pakhtunkhwa, Pakistan. danishsaeed48@gmail.com.
Naunyn-Schmiedeberg's archives of pharmacology
|October 3, 2024
概括
这项研究开发了含阿托瓦斯塔丁的自我纳米乳化药物输送系统 (SNEDDS),以提高生物可用性. 与市场上销售的片剂相比,桑涂层的SNEDDS通过肺部输送显示出优异的抗高脂效应.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 纳米技术纳米技术
背景情况:
- 阿托瓦斯塔丁是一种广泛使用的药物,用于管理高脂血症.
- 口服阿托瓦斯塔丁的生物可用性较差,需要使用替代的输送策略.
- 自行纳米乳化药物递送系统 (SNEDDS) 提供了增强药物吸收的潜力.
研究的目的:
- 开发和描述阿托瓦斯塔丁载荷的SNEDDS,以提高生物可用性.
- 评估SNEDDS的空气动力学性能和肺部输送潜力.
- 在体内评估开发的SNEDDS的抗高脂效.
主要方法:
- 使用油酸,Tween 80和Span 80通过自发乳化来制备SNEDDS.
- 特性包括粒子大小,泽塔潜力,形态,药物含量,表面张力和粘度.
- 使用安德森级联冲击器评估了空气动力学性能.
- 在Wistar大鼠中评估了抗高脂活性.
主要成果:
- 在SNEDDS中,粒子大小在36-311nm之间,PDI为0.25-0.40和负泽塔电位 (-29.22到-38.26mV).
- 酸盐涂层的SNEDDS (F5) 具有较高的粘度和较低的表面张力.
- 雾化SNEDDS获得了高分散 (87-97%) 和吸入 (74-87%) 分数,F4显示出优异的气溶化.
- 与商业阿托瓦斯塔丁片相比,桑涂层的SNEDDS显示出增强的抗高脂效应.
结论:
- 携带阿托瓦斯塔丁的SNEDDS被有效地开发为潜在的肺部输送.
- 粒子大小和表面特性显著影响空气动力学性能.
- 桑涂层的SNEDDS显示出通过吸入的卓越的全身传递和抗超脂血性疗效的承诺.
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