结直肠癌治疗后的非胃肠道症状负担 - 一项系统性审查
Darren Fernandes1,2, David Nelson3,4, Marishona Ortega5
1The Department of Gastroenterology, United Lincolnshire NHS Trust, Lincoln County Hospital, Lincoln, UK. darren.fernandes@nhs.net.
概括
大肠直肠癌幸存者经常经历长期的非胃肠道症状,影响生活质量. 本审查使用问卷识别了这些影响和评估方法.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 系统审查是系统的审查.
背景情况:
- 结肠直肠癌是全球普遍存在的恶性瘤,由于查和治疗的进步,其生存率有所提高.
- 癌症治疗,包括手术,放射治疗和化疗,可以导致持续的胃肠道和非胃肠道症状.
- 了解这些长期的非胃肠道症状对于改善患者护理和生活质量至关重要.
研究的目的:
- 系统地审查和理解患者经历的长期结直肠癌治疗后的非胃肠道症状.
- 通过验证的问卷来确定如何评估这些症状.
主要方法:
- 在多个数据库 (Scopus,PubMed,Web of Science,PsycINFO,Cochrane Library) 进行了系统的文献搜索,遵循PRISMA的指导方针.
- 包括的研究集中在治疗后至少持续12个月的非胃肠道症状上,不包括缓解性或复发性癌症病例.
- 分析了2012年2月至2024年7月期间以英语出版的文章.
主要成果:
- 37项研究符合纳入标准,主要是定量和横截面设计,其中大多数是在荷兰进行的.
- 使用了45个经过验证的问卷,测量了对生活质量,情绪困扰,性和泌尿功能障碍,神经病变,疲劳和部疼痛的影响.
- 参与者的人口统计数据显示,大多数是男性,年龄从29岁到89岁不等.
结论:
- 许多长期的非胃肠道症状对结直肠癌幸存者的生活质量产生了负面影响.
- 审查强调了解决营养,体育活动,精神和沟通在管理这些持续的副作用的重要性.
- 经过验证的问卷是识别和评估这些症状负担的重要工具.
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