在跨性别女性中患前列腺癌的患病率和相关因素
Celeste Manfredi1,2, Antonio Franco1,3, Francesco Ditonno1,4
1Department of Urology, Rush University Medical Center, Chicago, Illinois.
JAMA oncology
|October 3, 2024
概括
前列腺癌 (PCa) 在跨性别女性中不常见. 性别确认激素治疗 (GAHT) 可能会降低PCa风险,但会增加那些被诊断为PCa的人的生化复发和骨转移风险.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 关于跨性别女性前列腺癌 (PCa) 患病率和风险因素的证据有限.
- 解决PCa知识和跨性别人士的医疗保健方面的性别差异至关重要.
研究的目的:
- 为了确定PCa在美国跨性别女性中的患病率.
- 确定与PCa诊断,生化复发 (BCR) 和骨转移 (BM) 相关的因素.
主要方法:
- 一项回顾性队列研究分析了来自PearlDiver Mariner的12年的 (2011-2022) 美国索赔数据.
- 包括跨性别女性在跨性别身份代码之前被认定为男性,PCa检测是关键结果.
主要成果:
- 该研究包括95,460名跨性别女性;PCa患病率为0.62% (589人).
- 年龄和家族病史与PCa风险增加有关.
- 性别确认激素治疗 (GAHT) 与较低的PCa风险,但较高的BCR和BM风险有关.
结论:
- 在跨性别女性中,前列腺癌似乎相对不常见.
- GAHT可能会降低PCa的发生率,但可能会增加PCa的跨性别女性的BCR和BM风险.
- 需要进一步的研究来验证这些发现.
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