具有"杀死-排斥-杀死"三重功能的杀菌和防涂料,基于具有结构转换和素模拟释放的阴离子共聚物
Xiuhua Sun1, Zhiren Guo1, Qingmei Huang1
1School of Marine Science and Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China.
ACS applied materials & interfaces
|October 3, 2024
概括
这项研究开发了一种新型的共聚物,可以以受控的方式释放一种杀菌剂N-(4-基-3-甲基) 烯胺 (HMBA). 由此产生的涂层具有出色的抗和杀菌性质,可以快速排斥和杀死诸如大肠杆菌 (E. coli) 等细菌.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 生物医学工程 生物医学工程
背景情况:
- 开发具有抗微生物特性的先进材料对于预防感染和生物污染至关重要.
- 需要控制释放系统来持续提供抗菌剂.
- 聚合物设计为可调节的材料特性和功能提供了机会.
研究的目的:
- 合成和表征能够控制释放杀菌剂的两性共聚物.
- 调查控制共聚合物水解和药物释放的结构性质关系.
- 评估共聚合物基涂料的抗和杀菌功效.
主要方法:
- 通过四级化合成的N-(4-基-3-甲基) 烯胺 (HMBA) -功能化聚氨基甲酸盐 - 块聚(2-(N,N-二甲基胺) 乙基甲酸盐 (PLMA-b-PDMAEMA) 共聚物.
- 使用1H NMR光谱学对共聚合物结构和溶剂反应性行为的表征.
- 在不同的温度和pH条件下评估水解动力学.
- 在体外评估蛋白质排斥力,对大肠杆菌和金黄色杆菌的杀菌活性,以及最小抑制度 (MIC).
主要成果:
- 两性共聚合物被成功合成,在应对溶剂极性时表现出结构转变.
- 在水中对共聚合物的水解产生了zwitterionic表面和HMBA的受控释放,释放速度取决于温度,pH值和水友性块含量.
- 涂料表现出显著的抗和杀菌性能,大肠杆菌粘附率在1小时内降至<1%,细菌存活率<1%.
- 该PLMA120-b-(PDMAEMA-AAMPCA) 120共聚合物表现出强烈的抗菌活性,MIC为0.078 mg/mL对抗S. aureus和0.312 mg/mL对抗E. coli.
结论:
- 开发的共聚物为通过受控的水解和药物释放创造先进的抗和杀菌材料提供了一个有前途的平台.
- 聚合物的可调性性质允许根据特定应用要求优化抗菌性能.
- 这些材料有可能用于医疗器械,涂料和其他需要有效控制细菌的领域.
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