运动神经元疾病与艾滋病毒感染之间的关联:对病例报告的系统审查
João Paulo Moreira Fernandes1, Leonardo Peixoto Garcia1, Felipe Araújo Gouhie1
1School of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Brazil.
International journal of STD & AIDS
|October 3, 2024
概括
运动神经元疾病 (MND),包括肌缩侧面硬化症 (ALS),可以影响艾滋病毒感染者. 抗逆转录病毒疗法 (ART) 显示出改善这些患者治疗结果的潜力.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 运动神经元疾病 (MND) 包含神经退行性疾病,其中肌缩侧面硬化症 (ALS) 是最常见的.
- 自1985年以来,已经注意到MND/ALS和艾滋病毒感染之间的潜在联系.
研究的目的:
- 系统地审查病例报告和艾滋病毒感染者 (PLWH) 被诊断为MND/ALS的人群系列.
- 在艾滋病毒感染的背景下分析MND/ALS的临床表现,治疗和结果.
主要方法:
- 使用PubMed,Bireme,Embase和Lilacs数据库进行了系统审查.
- 包括HIV和MND/ALS患者的病例报告和病例系列.
- 用Joanna Briggs Institute (JBI) 案例报告的批判性评估工具来评估偏见的风险.
主要成果:
- 该审查分析了36篇文章,详细介绍了PLWH中88例MND/ALS病例,平均年龄为41.6岁.
- 大多数患者 (89.8%) 接受抗逆转录病毒疗法 (ART).
- 常见的症状包括束 (69.8%) 和过度反射 (58.8%). 在接受ART的患者中,54.6%的患者出现了临床改善,活着的患者的平均存活时间为62个月.
结论:
- 在PLWH中,MND/ALS在年轻人中可能呈现为快速进展的疾病.
- 抗逆转录病毒疗法 (ART) 显示出改善这一群体的衰弱和生存率的潜力.
- 呼吸衰竭是已故患者的主要死亡原因.
相关概念视频
Sexually Transmitted Infections
2.0K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
2.0K
Cytomegalovirus Disease
102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Multiple Sclerosis l: Introduction
20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
Parkinson Disease ll: Pathophysiology
28
Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
28
Huntington Disease l: Introduction
110
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
110


