复发性阴道膜炎的维持药理疗法. 随机研究的贝叶斯网络元分析
Barbara Gardella1, Chiara Cassani1, Mattia Dominoni1
1Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
概括
每周的维持疗法,包括口服的可纳/伊特拉可纳,可纳和局部的克洛特里马,有效地预防了早期复发性阴道 (RVVC) 复发. 奥特塞可纳在停止治疗后预防晚期RVVC复发方面表现出卓越的疗效.
科学领域:
- 菌类学 菌类学是指菌类学.
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 复发性 vulvovaginal candidiasis (RVVC) 影响了许多女性,需要有效的维持疗法.
- 可用的治疗方法包括各种口服和局部药理选择.
研究的目的:
- 评估口服和局部药理维护疗法的有效性,以预防早期和晚期RVVC复发.
- 为了比较与不同治疗方案相关的临床和真菌学复发风险.
主要方法:
- 对主要数据库 (PubMed,EMBASE,Cochrane Library,OVID) 和临床试验注册表进行了系统的搜索.
- 包括评估RVVC药理预防的随机对照试验.
- 用贝叶斯网络元分析来评估治疗效果和排名.
主要成果:
- 与安慰剂相比,每周口服的oteseconazole,口服的fluconazole/itraconazole和局部的clotrimazole显著减少了早期的RVVC复发.
- 在停止治疗后,每周一次的弗卢科纳/伊特拉科纳和每月一次的局部治疗仍然有效.
- 每周的oteseconazole在预防晚期临床和真菌性RVVC复发方面显著更有效.
结论:
- 每周使用口服弗卢科纳/伊特拉科纳,奥特塞科纳或局部克洛特里马进行维护疗法,对早期RVVC预防有效.
- 奥特塞可纳显示出卓越的长期疗效,在停止治疗后,将RVVC复发率降低了90%以上.
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