污泥排水系统的空气抗生素耐药性:流动性,病原体的可访问性,跨媒介迁移倾向性,影响因素和风险
Tang Yang1, Xuyi Wang1, How Yong Ng2
1School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao 266520, PR China.
Water research
|October 3, 2024
概括
污泥排水系统会将空气中的抗生素耐药性基因 (ARG) 和细菌释放到空气中,造成比以前理解的更大的健康风险. 冬季条件加剧了这种生物气溶污染,凸显了减缓策略的必要性.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 空气污染 大气污染
背景情况:
- 污泥排水系统 (SDS) 是生物气溶污染的潜在来源.
- 来自SDS的空气传播抗生素耐药性相关的排放和风险尚未得到充分理解.
- 抗生素耐药性对全球健康构成重大威胁.
研究的目的:
- 调查抗生素耐药性基因 (ARG) 和致病性抗生素耐药性细菌 (PARB) 在SDS内部和周围的细颗粒物 (PM2.5) 中的季节性动态.
- 评估脱水过程对抗体的气溶化的贡献.
- 评估影响SDS相关PM2.5.5抗生素耐药性的环境因素.
主要方法:
- 从SDS和环境空气中季节性收集的PM2.5样本的元基因组学分析.
- 污水污泥对ARG和PARB的分析.
- 环境因素 (相对湿度,温度,PM2.5度) 和细菌社区演变之间的相关性分析.
主要成果:
- 与环境空气PM2.5.5相比,与SDS相关的PM2.5呈现出更高的ARG的积累,转移和病原体可访问性.
- 移动ARG,主要是赋予四环素耐药性,经常与整合酶相关,在SDS-PM2.5.5中普遍存在.
- 脱水过程从污水污泥中空气化了50%以上的ARG亚型和42%的PARB.
- 鉴定出Enterobacter asburiae,Escherichia coli,Enterococcus faecium和Staphylococcus aureus是携带移动遗传元件的PARB.这些细菌被确定为携带移动遗传元件的PARB.
- 相对湿度,温度和PM2.5度影响了SDS-PM2.5.5.中的细菌群落和抗生素耐药性.
- 与污水污泥和环境空气PM2.5相比,SDS-PM2.5的耐药性风险更高,在冬季观察到的峰值水平.
结论:
- 脱水行为是抗生素耐药性基因和细菌气溶化的重要因素.
- 特别是在冬季,SDS-PM2.5是空气传播抗生素耐药性的重要来源.
- 缓解策略是必要的,以解决与SDSs的生物气溶污染相关的这种潜在的公共卫生风险.
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