结核病和过敏小麦敏感性的共存:日常临床实践的观察性研究
Tugba Onalan1, Fatih Colkesen1, Tacettin Akcal2
1Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
International archives of allergy and immunology
|October 3, 2024
概括
在小麦过敏患者中,小麦敏感化和腹腔疾病可以并存,在小麦过敏患者中,腹腔抗体阳性度更高. 这表明肠道屏障功能受损与对小麦的双重免疫反应之间存在潜在联系.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 过敏 过敏是一种过敏.
背景情况:
- 通过IgE介导的小麦敏感化和腹腔疾病 (CD) 涉及不同的免疫路径,但可以同时发生.
- 临床观察对于理解这种关系的实际含义至关重要.
研究的目的:
- 在临床环境中调查小麦敏感化和腹腔疾病的同时发生情况.
- 评估同时对两种疾病进行查的诊断价值.
主要方法:
- 同时对患有CD症状的患者进行了乳抗体 (CA) 查和食物刺痛测试 (FPT).
- 阳性CA的患者接受了内镜检查;在之前诊断为CD的患者中,分析了FPT结果.
主要成果:
- 在169名患者中,小麦刺伤阳性 (WP+) 发现在1名CD患者和14/65名 (20.3%) 非乳性WP+患者中,这些患者是CA+.
- 与WP-组相比,WP+组的CA+状态显著更高 (p=0.023).
- 在患有WP+和CA+的患者中,发现了四名以前未被诊断的CD患者.
结论:
- 在小麦刺痛阳性和乳抗体阳性之间存在显著的关联.
- 这表明肠道屏障受损与与小麦同时发生的Th1/Th2炎症反应之间存在潜在的联系.
- 需要进一步的研究来证实这些发现并阐明潜在的机制.
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