根据一次性 soma 理论,永恒性是可能的,但系统复杂性使其不太可能
Christopher W Rodriguez1, Peter W Reddien1
1Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, 02142, MA, USA.
Journal of theoretical biology
|October 3, 2024
概括
进化可能有利于动物的永恒性,如果损伤严重,修复不昂贵. 然而,具有多个损伤源和修复机制的复杂生物不太可能演变为完全不衰老.
科学领域:
- 进化生物学 进化生物学
- 老年学是一门学科.
- 理论生态学理论生态学
背景情况:
- 人口统计研究表明,一些物种缺乏衰老,这挑战了进化理论.
- 经典理论努力解释不老的进化.
- 一次性 soma 理论为了解衰老提供了一个框架.
研究的目的:
- 通过使用数学模型,识别有利于不衰老的进化条件.
- 探索损坏严重程度,维修成本和环境因素的作用.
主要方法:
- 基于一次性 soma 理论的数学模型的开发.
- 分析完全消除加速衰老的损伤的条件.
- 包括诸如外部死亡率和密度依赖调节等因素.
主要成果:
- 如果损伤风险很高,并且修复在繁殖方面很便宜,那么无年龄可以在进化上受到青.
- 环境因素显著影响最佳衰老率和不衰老的有利性.
- 多种损伤来源和独立的修复过程使得复杂的生物体不太可能存在无衰老.
结论:
- 进化不老是可能的,但仅限于特定的,狭窄的背景.
- Pleitotropic 修复过程可以增加不衰老的可能性,但不能保证它.
- 在多细胞生物体中,损伤和修复机制的复杂性通常有利于老化而不是不老化.
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