聚二和2型糖尿病中癌症风险之间的关联:生活方式的改变效应
Peiwen Li1, Yu Wang1, Qianying Liu1
1Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chemosphere
|October 3, 2024
概括
暴露于非二氧化类多双 (NDL-PCBs) 会增加2型糖尿病患者的癌症风险. 健康的生活方式可能会减轻这种风险,这表明潜在的公共卫生干预措施.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 癌症是糖尿病患者死亡的重要原因之一,环境因素也在其中发挥作用.
- 像多二 (PCB) 这样的内分泌干扰物与环境健康问题有关.
研究的目的:
- 评估2型糖尿病 (T2DM) 患者血清指标-PCB水平与癌症风险之间的关联.
- 探索生活方式因素对PCB和癌症发病率之间的关系的改变作用.
主要方法:
- 对2806名T2DM患者的队列进行了大约10年的跟踪,确定了320例发生癌症.
- 考克斯的比例危险和竞争风险回归模型评估了PCB与癌症的关联.
- 生活方式因素 (BMI,体力活动,饮食等) 用于创建一种生活方式得分.
主要成果:
- 非二氧化类PCB (NDL-PCB) 的每一个四分位数间范围的增加与癌症发病率的8%-30%的增加相关.
- 高水平的特定PCB (PCB-52,PCB-101,PCB-138) 和低化PCB显著增加了癌症风险.
- NDL-PCB与胃肠道和呼吸道癌症有关,特别是肝癌,结肠直肠癌和肺癌.
- 健康的生活方式减轻了与较高PCB水平相关的癌症风险.
结论:
- NDL-PCB与T2DM患者的癌症风险增加有关.
- 促进健康的生活方式可能对减少PCB等环境污染物的不良健康影响至关重要.
- 研究结果支持环境和公共卫生战略,降低糖尿病人群的癌症风险.
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