来自Artemisia atrovirens的生长型基和它们的抗炎活性
Chunping Tang1, Yongzhe Zheng2, Zhengguang Shao2
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; China-Serbia "Belt and Road" Joint Laboratory for Natural Products and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Fitoterapia
|October 3, 2024
概括
亚特米西亚亚特罗维伦斯 (Artemisia atrovirens) 产生了十种新的生殖子基,包括罕见的二聚体. 一种化合物表现出强烈的抗炎活性,突出的是Artemisia.
科学领域:
- 自然产品化学 自然产品化学
- 植物化学 植物化学
- 药用化学 医学化学
背景情况:
- 阿尔特米西亚植物是各种生物活动的丰富来源.
- 已知有基尔马克兰类型的基,但它们在Artemisia atrovirens中的存在此前未得到证实.
研究的目的:
- 系统地研究Artemisia atrovirens的化学成分.
- 发现和描述来自该物种的新型甲.
- 评估隔离化合物的抗炎潜力.
主要方法:
- 从Artemisia atrovirens中分离和净化化合物.
- 使用质谱 (MS),红外 (IR),核磁共振 (NMR) 光谱 (1D和2D) 阐明结构.
- 单晶X射线衍射,密度函数理论 (DFT) NMR和时间依赖的DFT电子循环二元化 (TDDFT ECD) 计算用于结构确认.
- 在体外抗炎测定使用LPS刺激的RAW 264.7小鼠巨细胞来测量氧化 (NO) 生产.
主要成果:
- 确定了10种新的生殖类型的基和3种已知的类似物.
- 两种罕见的二面体生殖类型化合物在分离物中.
- 化合物10显著抑制了氧化的产生,其IC50值为4.01±0.09μM.
- 通过先进的光谱和计算方法实现了全面的结构特征.
结论:
- 这项研究代表了Artemisia atrovirens中生殖型基烯的首次报告.
- 这些发现扩大了Artemisia物种已知的化学多样性.
- 化合物10显示出有前途的抗炎性质,这表明药物开发的潜力.
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