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肺部结构和心脏结构和功能的纵向变化:MESA COPD研究

Emilia A Hermann1, Yifei Sun2, Eric A Hoffman3

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科学领域:

  • 心脏病学 心脏病学
  • 肺部病理学 肺部病理学
  • 医疗成像医学成像

背景情况:

  • 横截面研究显示肺结构和心脏功能之间存在关联.
  • 关于COPD等肺部疾病与心脏变化之间的关系的纵向数据有限.
  • 之前的研究表明,呼吸道疾病与肺心脏,肺和心脏输出量减少之间存在联系.

研究的目的:

  • 研究肺结构与心脏结构和功能之间的纵向关联.
  • 为了检查气道壁面积和肺气对6年内心脏参数的影响.
  • 提供COPD和心血管变化之间的相互作用的纵向数据.

主要方法:

  • 利用了多民族动脉样硬化研究 (MESA) COPD研究的数据,这是一项纵向病例对照研究.
  • 使用计算机断层扫描测量了细分气道壁面积 (WA) 和百分比的肺气.
  • 在基线和6年随访时通过心磁共振成像 (cMRI) 评估右心室和左心室参数.
  • 采用混合模型来分析纵向关联,调整相关共变量.

主要成果:

  • 在入学时,更大的气道壁面积与右心室质量的纵向增加相关.
  • 更高的百分比肺气与持续的左下心室终端透支体积有关.
  • 肺气的增加也与研究期间心脏输出量稳定下降有关.

结论:

  • 心脏结构和功能的变化与多民族队列中的6年肺结构有关.
  • 气道壁面积在纵向上与增加右心室质量有关.
  • 肺与左心室填充量和心脏输出量的稳定下降有关.