目前的药物治疗和营养治疗与酒精有关的肝病
Josiah E Hardesty1, Craig J McClain2
1Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, USA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Louisville, Louisville, KY, USA.
Clinics in liver disease
|October 3, 2024
概括
与酒精相关的肝病 (ALD) 患者面临营养不良的风险. 本综述涵盖了营养的营养.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 营养科学 营养科学
- 内部医学 内部医学
背景情况:
- 与酒精相关的肝病 (ALD) 与高空热量摄入有关,增加营养不良的风险.
- 在ALD中营养不良可以表现为微量营养素或宏量营养素缺乏.
- 皮质类固醇是严重的酒精相关性肝炎 (AH) 的标准治疗方法,但在某些患者中有效性有限.
研究的目的:
- 审查与酒精相关的肝病中的关键营养概念.
- 讨论最近关于预测AH患者皮质类固醇反应的发现.
- 探索酒精相关肝炎患者的预后指标.
主要方法:
- 文献综述侧重于ALD中的营养.
- 对最近关于预测皮质类固醇治疗结果的研究进行分析.
- 对与酒精有关的严重肝炎的预后标志物的检查.
主要成果:
- 营养不良是ALD的重要并发症,影响患者的健康.
- 预测模型,如利尔得分,有助于识别对皮质类固醇无反应者.
- 了解营养状况和预测标记可以改善AH患者的管理.
结论:
- 优化营养对于管理ALD患者至关重要.
- 准确预测皮质类固醇反应对于定制AH治疗至关重要.
- 预后评估有助于在严重的AH的临床决策.
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