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管理PSMA向放射性药物治疗的最佳患者护理实践

Jeremie Calais¹, Michael J Morris², Ayse Tuba Kendi³

¹Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|October 3, 2024

概括

使用177Lu vipivotide tetraxetan治疗转移性割抵抗性前列腺癌 (mCRPC) 需要对不良事件和辐射安全给予密切关注. 教育和多学科合作是最佳患者治疗结果的关键.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
放射性药物疗法是一种放射性药物疗法.

背景情况:

转移性割抵抗性前列腺癌 (mCRPC) 的管理协议正在随着新疗法而发展.
177Lu vipivotide tetraxetan ([177Lu]Lu-PSMA-617) 是一种针对PSMA的放射性药物,在VISION研究后获得批准.
新疗法需要更新患者管理指南,包括不良事件 (AE) 监测和辐射安全.

研究的目的:

为在mCRPC中提供针对PSMA的放射性药物治疗 (RPT) 的最佳实践指南.
为弥补AEs管理和[177Lu]Lu-PSMA-617.的辐射安全方面的教育差距.
强调患者咨询和多学科合作的重要性.

主要方法:

审查已发表的证据和关于前列腺癌中RPT管理的指导方针.
借鉴VISION研究调查人员的经验.
确定有关AE和辐射安全的教育需求.

主要成果:

关于AE (例如,疲劳,口腔干燥) 和辐射安全的教育对于有效的治疗和管理患者期望至关重要.
[177Lu]Lu-PSMA-617通常耐受良好,但可能需要诸如剂量调整,药物或输血等干预措施.
尿失禁对辐射安全构成挑战,需要谨慎管理.

结论:

[177Lu]Lu-PSMA-617的最佳患者管理依赖于全面的患者咨询和医疗瘤学家和核医学团队之间的强有力的多学科合作.
遵守辐射安全协议和持续监测对于安全有效的患者护理至关重要.
对于每位接受PSMA向性RPT的患者来说,个性化益处风险评估至关重要.

关键词:

不良事件不良事件不良事件转移性割抵抗性前列腺癌多学科的管理管理.前列腺特异性膜抗原前列腺特异性膜抗原放射性药物疗法是一种放射性药物疗法.

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