相关实验视频

Updated: Jun 11, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

作为治疗剂的226Ac的临床前评估:成像,剂量测量和治疗

Helena Koniar^1,2, Luke Wharton³, Aidan Ingham³

¹Life Sciences Division, TRIUMF, Vancouver, British Columbia, Canada; hkoniar@triumf.ca.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|October 3, 2024

概括

这项研究表明,Actinium-226 (226Ac) 放射性药物可以用于诊断和治疗神经内分泌瘤. 用226Ac-crown-TATE治疗显著延长了小鼠的生存时间,没有观察到毒性.

科学领域:

核医学是一种核医学.
放射性药物疗法是一种放射性药物疗法.
热门节目热门节目热门节目

背景情况:

动-226 (226Ac) 是一种具有诊断性玛辐射和治疗性阿尔法辐射的光放射性同位素.
226Ac的特性允许定量SPECT成像和体内α粒子生成,这表明独立的光学潜力.

研究的目的:

评估一个临床前的226Ac放射性药物,以测量其色疗效.
提出第一个使用226Ac.Ac.的向性α疗法研究.

主要方法:

226Ac被生产并标记为化剂-生物结合物冠-TATE.
放射性药物[226Ac]Ac-crown-TATE针对NRG小鼠的神经内分泌瘤进行SPECT成像,生物分布和治疗.
进行了定量SPECT/CT成像,生物分布研究和剂量计计算. 治疗包括给药125,250或375kBq的[226Ac]Ac-皇冠-TATE.

主要成果:

定量SPECT成像证实了[226Ac]Ac-crown-TATE的体内生物分布,与体外测量一致.
观察到高瘤吸收率 (>30%IA/g在5h) 和保留率,平均吸收剂量系数为222mGy/kBq.
在治疗组中,中位生存时间从7天 (对照组) 增加到16天,24天和27天,瘤生长减缓,没有观察到毒性.

结论:

226Ac证明了作为一个独立的治疗同位素的治疗潜力,补充了其诊断能力.
该研究支持在匹配的225Ac放射性药物中用于剂量测量评估的226Ac的使用.
需要进一步的研究来确定226Ac放射性药物的最大剂量和毒性.

关键词:

226Ac 226Ac 是一个这是SPECT成像系统.临床前的放射性药物制药.有针对性的α-治疗.他们是天文学家.

更多相关视频

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

相关概念视频

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...