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Updated: Jun 13, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.0K

甲素B通过调节衰老调节机制来促进Aβ蛋白毒性

Atif Ahmed Siddiqui1, Emmanuelle Merquiol2, Reut Bruck-Haimson1

  • 1Department of Biochemistry and Molecular Biology, the Institute for Medical Research Israel-Canada (IMRIC) The Hebrew University, Jerusalem, 9112001, Israel.

Nature communications
|October 3, 2024
PubMed
概括

蛋白酶甲素B (CTSB) 通过影响衰老途径,使阿尔茨海默病 (AD) 的粉样β毒性恶化. 然而,CTSB对不同类型的有毒蛋白质有相反的影响,这表明需要针对性神经退行性疾病治疗.

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Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System09:52

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