中间前额叶皮层的乙胆信号传递调解了学习学习无助训练后学习积极回避反应的能力
Zuhair I Abdulla1, Yann S Mineur1, Richard B Crouse2
1Department of Psychiatry, Yale University, New Haven, CT, 06508, USA.
概括
在中部前额叶皮质 (mPFC) 中过度的乙胆 (ACh) 信号增强了负面记忆编码,导致与压力相关的行为. 在mPFC中调节ACh水平对雄性和雌性小鼠的影响不同.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 分子生物学分子生物学
背景情况:
- 大脑乙胆 (ACh) 水平升高与抑郁症和与压力相关的行为有关.
- 最佳的 ACh 功能对于像记忆形成这样的认知过程至关重要.
研究的目的:
- 调查中部前额叶皮层 (mPFC) 中ACh信号传递在学习的无助感中的作用.
- 为了确定mPFC中过度的ACH信号是否会加强负记忆编码.
主要方法:
- 在小鼠中利用学习的无助任务,涉及不可避免的压力因素和积极回避测试.
- 采用纤维光度与基因编码的ACH传感器来测量mPFC的ACH水平.
- 使用药理学和化学遗传学方法操纵的mPFC ACh水平.
主要成果:
- 在压力期间mPFC中的ACh水平与男性的逃生缺陷相关,但不是女性.
- 增加的mPFC ACh水平在两性中都引起了逃生缺陷.
- 抑制mPFC ACh神经元改善了男性的脱离,但在女性中恶化了它.
结论:
- 持续升高的mPFC ACh信号会导致与压力相关的不适应性行为.
- 在mPFC中的ACH信号在男性和女性之间的基于压力的学习中起着不同的作用.
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