瘤坏死因子超级家族的信号传导:癌症中的生命和死亡
Obada Ababneh1, Daisuke Nishizaki2, Shumei Kato2
1Faculty of Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan. oeababneh185@med.just.edu.jo.
Cancer metastasis reviews
|October 3, 2024
概括
瘤坏死因子 (TNF) 超级家族 (TNFSF) 和TNF受体超级家族 (TNFRSF) 的成员在癌症中具有复杂的作用. 本综述探讨了它们的双重促进和抗瘤活动以及癌细胞中的信号通路.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,但反应率仍然有限.
- 许多接受ICI治疗的患者经历了初级耐药性或随后的疾病进展.
- 瘤坏死因子 (TNF) 超级家族 (TNFSF) 和TNF受体超级家族 (TNFRSF) 的成员是免疫反应和细胞命运的关键调节者,在癌症中具有复杂的作用.
研究的目的:
- 审查TNFSF/TNFRSF成员在癌症中的多方面的作用.
- 突出特定的TNFSF/TNFRSF成员,特别是那些参与细胞死亡和共刺激的成员.
- 阐明它们的信号通路以及它们对癌细胞存活和死亡的影响.
主要方法:
- 在癌症研究中对TNFSF/TNFRSF家族成员的文献综述.
- 专注于死亡领域含有和共同刺激的成员.
- 对癌症生物学中涉及的信号通路的分析.
主要成果:
- TNFSF/TNFRSF分子表现出取决于环境的亲瘤或抗瘤活动.
- 在瘤发生过程中,TNF起到双重调解作用.
- 虽然抗TNF药物已被确立用于自身免疫性疾病,但它们的直接抗癌应用定义较少.
结论:
- TNFSF/TNFRSF成员代表了癌症治疗开发的复杂而有前途的领域.
- 了解它们复杂的信号传递对于利用它们在癌症治疗中的潜力至关重要.
- 需要进一步的研究来澄清它们在瘤学中的确切作用和治疗应用.
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