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在患有2型糖尿病的绝经后妇女中,骨微型架构和肉症之间的关联
Rimesh Pal1, Trupti N Prasad2, Sanjay K Bhadada2
1Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. rimesh.ben@gmail.com.
Archives of osteoporosis
|October 3, 2024
概括
在患有2型糖尿病的绝经后妇女中,肉症和肉性肥胖会对骨微观结构产生负面影响,而不是骨密度. 这表明这个人群中骨折风险增加.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 整形外科 整形外科 整形外科
背景情况:
- 2型糖尿病 (T2D) 增加了肉症的风险,这种疾病有助于骨脆弱.
- 石膏症和石膏性肥胖症越来越多地被认为是骨健康的重要因素.
研究的目的:
- 调查萨科佩尼亚/萨科佩尼性肥胖症与2型糖尿病的绝经后妇女骨质之间的关联.
- 使用第二代高分辨率外围定量计算断层扫描 (HR-pQCT) 来评估骨微架构.
主要方法:
- 包括患有T2D和高骨折风险的绝经后妇女 (≥50岁).
- 通过DXA评估骨矿物质密度 (aBMD),椎骨分数 (TBS) 和身体组成.
- 通过HR-pQCT评估骨微架构和通过手握强度 (HGS) 评估肌肉强度.
- 根据低HGS和低尾骨肌指数 (ASMI) 定义的肉类.
主要成果:
- 129名女性被分为正常,可能的肉症,非肥胖肉症和肥胖肉症组.
- 在基线特征,骨折发病率,HbA1c,aBMD或TBS之间没有观察到显著的差异.
- HR-pQCT显示,与对照组相比,sarcopenic/sarcopenic肥胖群体的体积 BMD 和微型结构明显较差.
结论:
- 骨质量,而不是骨密度,在患有T2D和sarcopenia/sarcopenic肥胖症的绝经后妇女中受到损害.
- 这些发现凸显了这个特定的患者亚组中骨折风险的潜在增加.
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