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Updated: Jul 16, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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用经过验证的液体染色体质谱法方法在血清中对抗体-药物合物的特定站点稳定性评估

Meiling Qi1, Chenyue Zhu1, Yi Chen1

  • 1Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China.

Journal of proteome research
|October 3, 2024
PubMed
概括

这项研究引入了一种新的方法,用于评估血清中各种结合部位的抗体-药物结合物 (ADC) 稳定性. 研究结果显示,稳定性存在显著差异,有助于ADC的早期发展.

关键词:
抗体 - 药物结合物从底部向上的蛋白质组学.结合酸的结合酸.多重反应监测多重反应的监测.相对量化的相对量化.稳定性分析分析 稳定性分析

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相关概念视频

Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...