妊娠36周的孕妇血管指数和血液动力学参数在孕期和已经存在的糖尿病中
A Szczepkowska1, S Lausegger1, I Papastefanou2
1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
概括
孕期糖尿病 (GDM) 和先前存在的糖尿病 (DM) 的女性在怀孕后期表现出血管疾病的早期迹象. 这表明这些人的长期心血管风险更高.
科学领域:
- 产科和妇科 产科和妇科
- 心血管健康 心血管健康
- 怀孕期间糖尿病 在怀孕期间糖尿病
背景情况:
- 孕期糖尿病 (GDM) 和先前存在的糖尿病 (DM) 与增加的孕产妇和胎儿风险有关.
- 了解这些怀孕中的血管和血液动力学变化对于风险评估至关重要.
- 第三个三个月的血管评估可以提供对潜在的长期心血管并发症的见解.
研究的目的:
- 为了比较母亲的血管指数和血液动力学参数在第三个三个月.
- 评估GDM怀孕,先前存在的DM和未受影响的怀孕之间的差异.
- 在糖尿病怀孕中识别血管疾病的早期标志物.
主要方法:
- 在35-37周怀孕时对6350例怀孕的前性观察研究.
- 非侵入性测量心动脉到大腿脉冲波速率,增强指数,心脏输出,中风体积,中心血压和心率.
- 在GDM,先前存在的DM和对照组之间比较血管和血液动力学参数.
主要成果:
- 与对照组相比,患有GDM和先前存在的DM的女性表现出更高的心力输出,心率,中心血压和脉冲波速度.
- 两组之间在中风体积或总外周电阻方面没有发现显著差异.
- 在GDM组中,接受甲福明治疗的患者心率高于接受饮食治疗的患者.
结论:
- 由GDM或先前存在的DM复杂化的怀孕在第三个三个月内表现出血管疾病的早期迹象.
- 这些血管变化可能有助于这些女性观察到的长期心血管风险增加.
- 需要进一步的研究来探索这些发现对心血管风险管理的影响.
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