Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Structure of Lipids03:38

Structure of Lipids

9.4K
9.4K
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

7.2K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
7.2K
Membrane Lipids01:32

Membrane Lipids

22.9K
Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
22.9K
What are Lipids?01:31

What are Lipids?

7.5K
Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
7.5K
Surface Membrane Barriers01:18

Surface Membrane Barriers

1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

1.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Immunologic Profiling of Immune-Related Cutaneous Adverse Events with Checkpoint Inhibitors Reveals Polarized Actionable Pathways.

Clinical cancer research : an official journal of the American Association for Cancer Research·2024
Same author

Alterations of Epidermal Lipid Profiles and Skin Microbiome in Children With Atopic Dermatitis.

Allergy, asthma & immunology research·2023
Same author

Staphylococcus aureus causes aberrant epidermal lipid composition and skin barrier dysfunction.

Allergy·2023
Same author

Dupilumab significantly improves skin barrier function in patients with moderate-to-severe atopic dermatitis.

Allergy·2022
Same author

GFI1-Dependent Repression of <i>SGPP1</i> Increases Multiple Myeloma Cell Survival.

Cancers·2022
Same author

Methodological Considerations for Lipid and Polar Component Analyses in Human Skin Stratum Corneum.

Cell biochemistry and biophysics·2021

相关实验视频

Updated: Jun 11, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.1K

皮肤脂质屏障:结构,功能和新陈代谢

Evgeny Berdyshev1

  • 1Department of Medicine, National Jewish Health, Denver, CO, USA. berdysheve@njhealth.org.

Allergy, asthma & immunology research
|October 4, 2024
PubMed
概括

皮肤脂质,特别是角层 (SC) 中的胺,对于屏障功能至关重要. 这些脂质的变化可以预测过敏性皮肤疾病.

科学领域:

  • 皮肤病学 皮肤病学
  • 生物化学 生物化学
  • 皮肤生物学 皮肤生物学

背景情况:

  • 脂质和蛋白质对于皮肤屏障功能至关重要.
  • 角质细胞的分化涉及独特的脂质代谢,导致陶胺主导角层 (SC).
  • 特殊的细胞外结构叫做片形成紧密的疏水层,防止水损失和病原体进入.

研究的目的:

  • 审查脂质在维持皮肤屏障功能中的作用.
  • 突出使用SC脂质和蛋白质生物标志物的潜力,以预测过敏性皮肤疾病.

主要方法:

  • 这是一篇综述性文章,总结了现有研究.
  • 分析关于皮肤脂质,角质细胞分化和屏障功能的科学文献.

主要成果:

  • 皮肤屏障的完整性在很大程度上取决于皮肤屏障的特定脂质成分,特别是胺.
  • 脂质代谢和角质细胞分化的调节失调可能会损害皮肤屏障功能.
  • 在SC中的生物标志物可能表明对过敏皮肤状况的倾向.

结论:

  • 脂质对皮肤屏障的完整性至关重要.
  • 对脂质和蛋白质生物标记物的SC测试在预测未来的过敏性皮肤疾病的出现方面显示出希望.
关键词:
脂质 脂质 脂质 是一种过敏原 过敏原 过敏原亚托邦性皮肤炎的发生陶化物是一种陶化物.湿疹和湿疹是一个问题.角质细胞 (keratinocytes) 是一种细胞.皮肤 皮肤 皮肤

更多相关视频

Profiling the Triacylglyceride Contents in Bat Integumentary Lipids by Preparative Thin Layer Chromatography and MALDI-TOF Mass Spectrometry
09:18

Profiling the Triacylglyceride Contents in Bat Integumentary Lipids by Preparative Thin Layer Chromatography and MALDI-TOF Mass Spectrometry

Published on: September 5, 2013

21.2K
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

18.2K

相关实验视频

Last Updated: Jun 11, 2025

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.1K
Profiling the Triacylglyceride Contents in Bat Integumentary Lipids by Preparative Thin Layer Chromatography and MALDI-TOF Mass Spectrometry
09:18

Profiling the Triacylglyceride Contents in Bat Integumentary Lipids by Preparative Thin Layer Chromatography and MALDI-TOF Mass Spectrometry

Published on: September 5, 2013

21.2K
Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
08:23

Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film

Published on: July 10, 2016

18.2K