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雄激素驱动SARS-CoV-2入口蛋白在鼻组织中的表达

Rong Rong Huang¹, Jenna M Giafaglione², Takao Hashimoto²

¹Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.

Journal of clinical and translational pathology

|October 4, 2024

概括

抗雄激素剥夺疗法可以通过降低上呼吸道中的病毒进入蛋白质来对男性的早期COVID-19有好处. 然而,它在晚期疾病中没有任何好处,这表明它在呼吸道中具有局部影响.

科学领域:

在COVID-19的病原发生过程中,
安德罗学与人类学
呼吸道病毒感染呼吸道病毒感染

背景情况:

男性的COVID-19发病率和死亡率高于女性.
由雄激素受体调节的病毒输入蛋白表达是一种潜在的因素.
雄激素剥夺疗法 (ADT) 试验在住院的男性COVID-19患者中产生了不确定的结果.

研究的目的:

在严重的COVID-19中调查ADT失败的生物学原因.
评估雄激素在调节病毒进入蛋白质表达中的作用.
在上下呼吸道有不同的作用.

主要方法:

免疫组织化学用于评估TMPRSS2和ACE2的表达.
在小鼠模型和人体组织中与雄激素受体表达的相关性分析.
鼠模型涉及割和ADT;来自健康捐赠者和COVID-19患者的人类组织.

主要成果:

割和ADT降低了TMPRSS2和ACE2在小鼠鼻上皮质,唾液和眼腺,但不是肺部.
人体组织分析表明,在早期的鼻腔阶段有潜在的ADT作用,而不是在SARS-CoV-2感染的晚期肺部阶段.

结论:

在COVID-19的早期,鼻阶段,ADT可能对男性患者有好处.
ADT的作用很可能是由于降低了上呼吸道中的病毒进入蛋白质的调节.
对于影响肺部的晚期COVID-19疾病,ADT似乎没有益处.

关键词:

这就是ACE2ACE2.安卓素剥夺疗法是一种安卓素剥夺治疗.雄激素受体的受体雄激素受体在 COVID-19 疫情中,这就是SARS-CoV-2病毒.这就是TMPRSS2的原因.病毒进入蛋白质.

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