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多菌株双菌补充剂对低出生体重新生儿肠道微生物群发育的影响:一项随机对照试验
Kenichi Takeshita1,2, Haruka Takei1, Saori Tanaka1
1Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan.
Bioscience of microbiota, food and health
|October 4, 2024
概括
多菌株Bifidobacterium补充剂有效丰富肠道微生物群,在低出生体重新生儿中具有有益的Bifidobacterium. 这种方法还有助于抑制致病细菌,如Clostridium spp. 没有任何不良事件.
科学领域:
- 微生物学 微生物学
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
背景情况:
- 单株Bifidobacterium物种是低出生体重新生儿的常见益生菌.
- 多菌株Bifidobacterium补充剂的疗效和安全性仍然不太清楚.
研究的目的:
- 调查多菌株Bifidobacterium补充剂在低出生体重新生儿中的有效性和安全性.
- 为了比较单株与三株Bifidobacterium对便微生物群组成的影响.
主要方法:
- 在新生儿重症监护室的36名低出生体重新生儿 (<2,000g) 被随机分类.
- 参与者接受了单菌株或三菌株Bifidobacterium和乳糖肠道治疗4周.
- 便微生物群分析的重点是1,2和4周的Staphylococcus和Bifidobacterium的相对丰度.
主要成果:
- 群体之间的葡萄球菌丰度没有显著差异.
- 三重菌株Bifidobacterium组在第2周和第4周显示出显著更高的Bifidobacterium丰度.
- 与单株组相比,三株组表现出较低的α多样性 (富含Bifidobacterium) 和减少的Clostridium丰度.
- 在这两组中都没有报告任何严重不良事件.
结论:
- 多菌株Bifidobacterium补充促进了新生儿肠道微生物群中的早期Bifidobacterium丰富.
- 这种方法可以抑制致病细菌,如Clostridium spp. 在低出生体重新生儿中.
- 多菌株补充似乎是安全有效的调节肠道微生物群在这个脆弱的人群.
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