肠道微生物群及其在格雷夫斯病中的作用:系统性审查和元分析
Hendra Zufry1,2, Putri Oktaviani Zulfa2, Timotius Ivan Hariyanto3
1Division of Endocrinology, Metabolism, and Diabetes, Thyroid Center, Department of Internal Medicine, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh 24415, Indonesia.
Bioscience of microbiota, food and health
|October 4, 2024
概括
与健康个体相比,格雷夫氏病 (GD) 患者的肠道微生物群多样性显著减少,细菌系发生变化. 这一元分析强调了肠道失调和GD发展之间的潜在联系.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 新出现的证据表明肠道细菌在Graves' Disease (GD) 病因学中起着作用,但这些发现是相互矛盾的.
- 了解肠道微生物对GD的影响对于推进治疗策略至关重要.
研究的目的:
- 为了研究肠道微生物组成和Graves病之间的相关性.
- 综合目前关于肠道微生物变化的研究,在GD患者.
主要方法:
- 在主要数据库 (科克兰图书馆,Scopus,欧洲PMC,Medline) 进行了系统的文献搜索,截至2023年8月1日.
- 使用随机效应模型的元分析被用来分析来自十项纳入研究的数据.
- 为微生物多样性指数计算了95%信心区间 (CI) 的标准化平均差异 (SMD).
主要成果:
- 与健康对照组相比,GD患者的α多样性显著减少,包括Chao1,ACE和Shannon指数.
- 在GD患者中观察到Firmicutes类的减少和Bacteroidetes类的增加.
- 分析证实,在患有GD的个体中,肠道微生物群的丰富性和多样性显著减少.
结论:
- 在患有格雷夫斯病的患者中,肠道微生物群的组成显著改变.
- 减少的微生物多样性和细菌类中的特定转变表明肠道失生症在GD病变发生过程中的潜在作用.
- 需要进一步的研究来阐明因果关系和治疗影响.
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