饮食炎症指数和女性不孕症:来自NHANES调查的发现
Wenhui Wang1, Yuxiao Dong2,3, Kun Wang2
1Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Frontiers in nutrition
|October 4, 2024
概括
通过饮食炎症指数 (DII) 衡量的促炎症饮食与20至44岁的美国女性的不孕率更高有关. 这凸显了饮食模式在生殖健康中的重要性.
科学领域:
- 生殖健康 生殖健康
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 不孕症影响着人口的很大一部分,并且越来越多地与炎症状况有关.
- 关于饮食模式,如饮食炎症指数 (DII) 对女性不孕症的具体影响的研究有限.
- 了解这些饮食影响对于公共卫生计划和生殖医学至关重要.
研究的目的:
- 为了研究饮食炎症指数 (DII) 与美国女性队列中的不孕症之间的关联.
- 为了确定更高的DII分数是否与不孕不育的患病率增加相关.
- 使用先进的统计方法探索潜在的贡献因素和关系.
主要方法:
- 这是一项横截面研究,利用来自国家健康和营养检查调查 (NHANES) (2013-2018) 3,071名女性 (20-44岁) 的数据.
- 饮食摄入数据被用来计算DII;不孕症状态是自我报告的.
- 调整的多变量逻辑回归,子组分析和受限立方线 (RCS) 模型被用于评估DII与不孕症的关联.
主要成果:
- 在DII和不孕症之间发现了显著的正相关性 (OR = 1.61).
- 与最低四分位数 (OR = 1.71) 相比,DII分数最高四分位数的女性患不孕的几率明显更高.
- RCS模型显示了一个S形曲线,表明更高的DII与增加的不孕症患病率有关,肥胖症是重要因素.
结论:
- 饮食炎症指数 (DII) 与20-44岁美国女性不孕症的可能性增加有关.
- 这些发现表明,促炎症饮食模式可能会对女性生育能力产生负面影响.
- 建议通过大规模前性队列研究进行进一步验证,以确认这些结果并为临床实践提供信息.
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