早期发育得分作为患有自闭症谱系障碍的非语言/极少语言儿童的预后因素:塞浦路斯的一项匹配病例对照研究
Margarita Kilili-Lesta1, Konstantinos Giannakou1, Louiza Voniati1
1Department of Health Sciences, European University Cyprus, Nicosia, Cyprus.
Autism & developmental language impairments
|October 4, 2024
概括
患有自闭症谱系障碍 (ASD) 的儿童早期发育迟缓与持续的语言障碍有关. 监测早期发育得分可以帮助识别患有非语言/最小语言 (NV/MV) 自闭症谱系障碍 (ASD) 风险的儿童.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科心理学 儿科心理学
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是社会和行为障碍.
- 患有自闭症儿童的大量子群体经历了持续的非语言/最小语言 (NV/MV) 沟通挑战,影响了他们的生活质量.
- 导致ASD语言结果减少的因素尚不清楚.
研究的目的:
- 在塞浦路斯诊断患有自闭症谱系障碍 (ASD) 的儿童中,确定与非语言/最小语言 (NV/MV) 结局相关的风险和预后因素.
主要方法:
- 一项涉及56名患有自闭症儿童 (3-12岁) 的病例控制研究,分为NV/MV (病例) 或口头 (对照).
- 追溯收集有关家族,围产和发育因素的数据,以计算风险得分 (FRS,PRS,DRS).
- 评估早期发育使用早期发育得分 (EDS) 和早期手势得分 (EGS) 来评估幼儿时期的里程碑.
主要成果:
- 高发育风险评分 (DRS),由低早期发育评分 (EDS) 驱动,与ASD的非语言/最小语言 (NV/MV) 状态显著相关.
- 与高EDS儿童相比,患有ASD和低EDS的儿童在NV/MV组的可能性是4.5倍.
- 低EDS反映了一般的早期发育迟缓,是ASD持续语言迟缓的主要预测因素.
结论:
- 跨多个领域的幼儿早期发育迟缓预测ASD儿童的后来的言语结果减少.
- 显示EDS分数较低的儿童具有更高的持续语言障碍的可能性,将其分类为NV/MV ASD.
- 密切监测早期发育对于识别患有NV/MV ASD风险的儿童和促进及时干预至关重要.
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