对纳米材料毒性对人类健康的影响的洞察
Wajhul Qamar1, Shweta Gulia2, Mohammad Athar3,4
1Department of Pharmacology and Toxicology and Central Laboratory, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
PeerJ
|October 4, 2024
概括
纳米材料提供了工业上的好处,但由于其独特的特性,它们会给健康带来风险. 本审查详细介绍了它们的毒性,暴露途径和评估方法,以实现更安全的设计.
科学领域:
- 纳米技术和材料科学 材料科学
- 环境健康和毒理学
- 生物医学工程 生物医学工程
背景情况:
- 纳米材料越来越多地用于电子,制造业和医药等行业.
- 它们独特的物理化学特性,与散装形式不同,引发了严重的毒理问题.
- 环境积累和潜在的不良健康影响需要对纳米材料风险有充分的了解.
研究的目的:
- 提供各种纳米材料的毒理学视角的全面审查.
- 阐明物理化学性质和纳米材料毒性之间的关系.
- 讨论暴露途径,生物分布和毒性机制,以更深入地了解纳米诱导反应.
主要方法:
- 对纳米材料毒理学现有文献的综述.
- 对影响毒性的物理化学性质的分析.
- 包括各种体内和体外毒性评估方法.
主要成果:
- 纳米材料的小尺寸有助于它们穿越生物膜,从而进入细胞,组织和器官.
- 环境释放导致积累,影响生态系统和生物.
- 观察到各种毒理效应,需要对机制进行持续研究.
结论:
- 了解纳米材料的毒性对于人类健康和环境安全至关重要.
- 对毒理反应的了解有助于设计更安全,更有效的纳米粒子.
- 持续的研究和监测对于管理与广泛使用纳米材料相关的风险至关重要.
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