背部注意网络中的功能连接的不同模式使精神分裂症和双相情感障碍患者区分开来
Adrian Andrzej Chrobak1, Sylwia Bielak2, Dominik Nowaczek3
1Department of Adult Psychiatry, Jagiellonian University Medical College, Kraków, Poland.
Frontiers in psychiatry
|October 4, 2024
概括
背部注意网络 (DAN) 中功能连接的改变可以区分精神分裂症 (SZ) 和双相情感障碍 (BD). BD患者的连接性较弱,而SZ患者在DAN中表现出更强的连接性,这表明了诊断的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 精神分裂症 (SZ) 和双相情感障碍 (BD) 分享重叠的症状,导致频繁的误诊.
- 大脑网络的改变,特别是在感知组织中,正在被用于差异诊断.
研究的目的:
- 调查背部注意网络 (DAN) 中的功能连接 (FC) 是否可以区分患有SZ,BD和健康对照 (HC) 的个体.
主要方法:
- 休息状态功能性磁共振成像 (fMRI) 用于90名参与者 (30 SZ, 30 BD, 30 HC).
- 在核心DAN节点内进行了FC的比较:前额眼球场 (FEF) 和眼内 (IPS).
主要成果:
- 与HC相比,BD患者在右和左FEF之间表现出较弱的半球间FC.
- 与HC不同的是,SZ患者在FEF和IPS之间增加了半球间和半球内FC,与HC不同.
- 与BD患者相比,SZ患者在右FEF和其他DAN节点 (双边IPS,左FEF) 之间表现出增加的FC.
结论:
- 在DAN中改变的静态FC有效地区分了SZ,BD和HC组.
- 在DAN中,BD中的低连接性和SZ中的超连接性可以作为差异诊断的候选生物标志物.
- 建议使用更大的样本大小进行进一步的研究,以验证这些发现.
关键词:
双相情感障碍是双相情感障碍的一种疾病.额头眼睛的眼球领域.功能性网络是一种功能性网络.顶层皮质 (parietal cortex) 是一个表面皮质.休息状态 休息状态精神分裂症是一种精神分裂症.更多相关视频
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