临床特征和预测因素的复发性异常性横侧髓炎
Eun Kyoung Lee1, Sooyoung Kim2, Eunhee Sohn2
1Department of Neurology, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.
Frontiers in neurology
|October 4, 2024
概括
超过20%的异常性横侧髓炎 (iTM) 患者经历了复发. 纵向扩展横侧髓炎 (LETM) 是复发的最重要的预测因素,表明在这种情况下需要仔细监测.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经炎症是一种神经炎症.
背景情况:
- 异常性横侧肌炎 (Idiopathic transverse myelitis,简称iTM) 是一种未知原因的炎症性脊髓疾病.
- 复发性iTM的特征尚不清楚,需要进一步研究.
研究的目的:
- 确定iTM患者复发的临床特征和预测因素.
- 要区分单相 (mTM) 和循环 (rTM) 的iTM.
主要方法:
- 在10年内对55名iTM患者进行了回顾性研究.
- 不包括多发性硬化和NMOSD诊断.
- 在mTM和rTM组之间比较临床和MRI发现.
主要成果:
- 20%的iTM患者经历了复发 (rTM).
- 复发性iTM与较低的维生素D水平和纵向广泛的横侧髓炎 (LETM) 相关.
- 女性性别,年龄较小,维生素D水平较低和LETM是复发的风险因素;LETM显著预测复发.
结论:
- mTM和rTM的临床特征相似,但LETM是复发的关键预测因素.
- 异形性rTM显示出良好的预后和对免疫治疗的反应.
- 在iTM中的 LETM 需要对复发风险保持警,即使不表明NMOSD.
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