影响动脉硬性和手腕-脚脉冲波速的因素在2型糖尿病患者中
Tomoki Furuya1,2,3, Shinji Kitahama4, Yuma Tamura5
1Department of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, Nikko, JPN.
Cureus
|October 4, 2024
概括
体重指数 (BMI) 与2型糖尿病患者的动脉样硬化进展有关. 26.28公斤/平方米的BMI截止值表明风险增加,突出显示BMI.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 动脉样硬化的进展是2型糖尿病 (T2DM) 的关键问题.
- 腕脉冲波速度 (ba-PWV) 是动脉硬和动脉样硬化的关键指标.
- 了解患者特征和动脉硬之间的相互作用对于T2DM管理至关重要.
研究的目的:
- 在T2DM患者中使用ba-PWV来定义动脉样硬化进展.
- 研究ba-PWV与身体组成,肌肉强度和患者因素之间的关系.
- 在这个人群中识别动脉硬度增加的显著预测因素.
主要方法:
- 评估了109名T2DM患者的动脉硬度 (ba-PWV),身体组成,人体测量,血液测试和患者数据.
- 使用后勤回归分析和协差分析进行统计评估 (p < 0.05).
- 将患者根据ba-PWV (≥或<1400厘米/秒) 分成两组,以确定独立变量.
主要成果:
- 高度ba-PWV的重要独立预测因素包括静缩血压 (OR = 1.11,p < 0.001),BMI和疾病持续时间.
- 确定身体质量指数 (BMI) 截止值为26.28公斤/平方米.
- 协同变量的分析证实BMI是ba-PWV的显著解释因素 (p < 0.001).
结论:
- 体重指数 (BMI) 与T2DM患者的动脉样硬化发病率有显著的关联.
- 超过26.28kg/m2的BMI与动脉硬度增加有关,这表明潜在的"代谢悖论".
- 这些发现强调了体重管理在减轻T2DM心血管风险方面的重要性.
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