赛美西康对高水平消毒剂的杀菌效果的影响
Gregory G Anderson1, Katharine Segars2, Anastacia M Sanchez1
1Division of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, USA.
Journal of medical microbiology
|October 4, 2024
概括
在内镜检查过程中使用的西米西康似乎没有降低Cidex正形甲消毒剂的有效性. 这项研究发现,再加工的内镜上的西美西康残留物没有增加微生物风险.
科学领域:
- 微生物学 微生物学
- 感染控制 感染控制
- 医疗设备再加工 医疗设备再加工
背景情况:
- 赛美西康常用于内镜手术,以改善可视化.
- 人们担心,内镜上的西美西康残留物可能会损害消毒效率并增加感染风险.
- 有限的直接证据解决了西美西康在再加工过程中对微生物风险的影响.
研究的目的:
- 评估赛美西康在体外对消毒剂有效性的影响.
- 为了确定西美西康残留物是否会影响用于内镜的消毒剂的杀菌活性.
主要方法:
- 细菌被培养在微型位板中,其度不同,并且有不同的simethicone度.
- 然后用消毒剂 (Cidex ortho-phthalaldehyde) 对细菌培养进行处理.
- 细菌活力通过甲进行评估,以确定消毒剂的有效性.
主要成果:
- 赛美西康没有降低Cidex正形甲消毒剂的疗效.
- 消毒剂至少减少了细菌生存能力的6个逻辑单位.
- 高度的西梅西康 (66毫克/毫升) 显示出直接的杀菌作用.
结论:
- 在测试条件下,西美西康似乎不会损害甲消毒剂的杀菌效果.
- 在内镜再处理过程中,西美西康残留的存在可能不会增加微生物的风险.
- 进一步的研究可能是有必要的,以探索simethicone与其他消毒剂和条件的相互作用.
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