两种语音和语言方法对帕金森病患者的语言问题的影响:PD COMM RCT:
Catherine M Sackley1,2, Caroline Rick3,4, Marian C Brady5
1Population Health Sciences, Addison House, King's College London, Guy's Campus, London, UK.
Health technology assessment (Winchester, England)
|October 4, 2024
概括
李·西尔弗曼语音治疗LOUD显著改善了与没有治疗相比,帕金森病患者的言语和语音问题. 然而,它没有被发现是具有成本效益的,国家卫生服务语音和语言治疗没有显著的好处比没有治疗.
科学领域:
- 神经学 神经学
- 语音语言病理学 语音语言病理学
- 卫生经济学 卫生经济学
背景情况:
- 发言障碍影响68%的帕金森病 (PD) 患者,增加了沟通挑战和社会孤立.
- 有效的语音和语言疗法对于改善PD患者的生活质量至关重要.
研究的目的:
- 为了比较李·西尔弗曼语音治疗LOUD (LSVT LOUD) 和国家卫生服务 (NHS) 语音和语言治疗 (SLT) 的临床和成本效益,与PD语言问题没有SLT.
- 评估不同SLT干预措施对语音障碍和PD患者报告结果的影响.
主要方法:
- 一个第三阶段,多中心,三臂,随机对照试验 (PD COMM) 涉及388名患有特异性PD和言语/声音问题的参与者.
- 参与者被随机分配到LSVT LOUD,NHS SLT或对照组 (没有SLT).
- 主要结局是3个月的语音障碍指数 (VHI) 总得分,次要结局评估到12个月.
主要成果:
- 与对照组 (p=0.001) 和NHS SLT (p<0.0001) 相比,LSVT LOUD在3个月内显著降低了语音问题的影响.
- 与对照组相比,NHS SLT没有显著改善 (p=0.4).
- LSVT LOUD比对照和NHS SLT更昂贵和更有效,但不具有成本效益.
结论:
- 与没有治疗相比,LSVT LOUD在帕金森病患者的言语和声音问题上提供了显著的好处.
- 在这项试验中,NHS SLT没有显示出相对于没有治疗的显著优势.
- 需要进一步的研究来探索LSVT LOUD或其他干预措施的成本效益.
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