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Updated: Jun 11, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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恩提选择性有机催化级联脱氧化旋环添加反应的Indole-Ynones

Chuan-Zhi Yao1, Xue-Qin Tu1, Zi-Yuan Zhao1

  • 1Department of Applied Chemistry, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, and Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Agricultural University, 230036 Hefei, China.

Organic letters
|October 4, 2024
PubMed
概括

一种新的有机催化级联反应,从烯前体中产生复杂的多循环螺旋. 这种高效的方法实现了高产量和出色的立体选择性,为有价值的化学结构提供了新的途径.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
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