脂复杂纳米载体的提取,分离,表征和开发,以提高黄素的可溶性,抗喘和药用动力学潜力
Darshan R Telange1, Pragati V Pandhare2, Krutika R Sawarkar2
1Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Sawangi (Meghe), Wardha 442004, Maharashtra, India.
Current pharmaceutical biotechnology
|October 4, 2024
概括
这项研究开发了一种新型的黄素-脂复合物 (CPLC),以增强黄素 (CUR) 的生物可用性和抗喘作用. 该CPLC配方显著改善了CUR的溶解性和口服吸收,显示出作为呼吸道纳米载体的前景.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 自然产品化学 自然产品化学
- 纳米技术纳米技术
背景情况:
- 黄长 (Curcuma longa Linn) 是一种植物. (Zingiberaceae) 含有具有显著生物活性的类素 (CUR).
- 由于溶解性差和快速清除,CURs的低口服生物可用性限制了临床使用.
研究的目的:
- 为了提取,隔离和描述CURs从Curcuma longa.
- 为CURs制定一种基于Phospholipon®90H的复合物 (CPLC).
- 评估CUR在CPLC中的可溶性,抗喘和药物动力学潜力的提高.
主要方法:
- 使用乙烯酸乙烯提取黄素 (CURs).
- 一种基于Phospholipon®90H的黄素复合物 (CPLC) 通过溶剂蒸发合成.
- 评估了物理化学性质,捕获效率,颗粒大小,泽塔潜力,可溶性,抗喘活性和口服生物利用性.
主要成果:
- 在CPLC中,CUR的高提取产量 (~17.42%) 和高捕获效率 (~92.55%).
- CPLC 呈现出小粒子大小 (~194 nm) 和负泽塔电位 (~-20.4 mV),表明稳定性.
- 在CPLC中,水溶性增加了约2倍,喘模型中的炎症细胞显著减少,并改善了CURs的口服生物可用性.
结论:
- 开发的CPLC配方增强了黄素的可溶性,抗喘活性和口服生物可用性.
- CPLC显示出作为一种突破性呼吸道纳米载体的潜力,用于呼吸道应用的库尔库米诺类药物和其他植物化合物.
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