半径轴轴低频超声波速度和骨脆弱性在初级甲状腺功能障碍症中的关联
Jessica Pepe1, Luciano Colangelo1, Daniele Diacinti2
1Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, "Sapienza" University of Rome, Italy.
The Journal of clinical endocrinology and metabolism
|October 4, 2024
概括
便携式低频超声波显示,在初级偏甲状腺症 (PHPT) 患者中查骨脆弱性具有前途. 这个工具可以帮助评估骨折风险,当DXA测量是不可行的.
科学领域:
- 内分泌学 在内分泌学.
- 骨质疏松症研究 骨质疏松症研究
- 医疗成像医学成像
背景情况:
- 原发性偏甲状腺症 (PHPT) 与骨折风险增加有关.
- 半径的定量超声波 (QUS),特别是便携式低频 (VLF) 轴传输超声波,已经显示出作为非PHPT人群骨脆弱性查工具的潜力.
- 在PHPT患者中评估VLF超声波的实用性对于改善骨健康评估至关重要.
研究的目的:
- 评估便携式VLF超声波设备在检查PHPT的绝经后妇女骨脆弱性的有效性.
- 为了比较VLF超声波测量与双能X射线吸收计 (DXA) 和PHPT患者的其他骨评估工具.
主要方法:
- 117名被诊断患有PHPT的绝经后妇女被纳入该研究.
- 参与者接受了股骨和腰椎的DXA扫描,TBS测量,脊椎X射线和非主导远端1/3半径的VLF超声波评估.
- 分析了半径DXA和VLF测量之间的一致性.
主要成果:
- 在半径DXA和VLF测量之间观察到适度一致 (K=0.43).
- 下半径VLFT得分与骨质疏松症相关,由DXA在腰椎和大腿部确定.
- 骨折风险与大腿T-score,部T-score,更年期以来的岁月和TBS显著相关,半径VLFT-score也显示与骨折的关联.
结论:
- 便携式VLF超声波可以作为一种有价值的查工具,用于评估PHPT患者的骨折风险,特别是当DXA无法访问时.
- 这些发现支持使用VLF超声波作为评估骨脆弱性的补充方法在这个患者群体.
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