过敏原免疫治疗的成本效益
Natalia Rodríguez-Otero1, Elena Ramírez-Mateo1, Maria Nieves Plana2,3,4
1Servicio de Alergia, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) Madrid, Spain. University of Alcalá (UAH).
Current opinion in allergy and clinical immunology
|October 4, 2024
概括
与标准护理相比,过敏原免疫疗法 (AIT) 是对过敏性鼻炎和喘的一种经济有效的治疗方法. 研究表明,AIT减少了药物需求和恶化,这表明长期价值更大.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 药物经济学 药物经济学
- 公共卫生 公共卫生
背景情况:
- 过敏性鼻炎影响全球5-50%的人口,与环境因素相关的流行率不断增加.
- 过敏原免疫疗法 (AIT) 是对过敏的唯一疾病修饰治疗方法,通过皮下和舌下途径证明有效.
- 过敏性鼻炎和喘的经济影响需要评估成本有效的治疗策略.
研究的目的:
- 审查AIT的药理经济学与过敏性鼻炎和喘的标准护理 (SOC) 相比.
- 分析最近 (24个月) 关于AIT的成本效益的文献.
- 评估AIT在管理过敏性呼吸道疾病中的价值.
主要方法:
- 发表文献的叙事审查.
- 对比AIT (皮下免疫疗法[SCIT]和舌下免疫疗法[SLIT]) 与SOC的研究分析.
- 包括测量质量调整寿命年 (QALYs),药物减少,症状得分和恶化情况的研究.
主要成果:
- 2022年的一项研究发现,SCIT和SLIT对儿童过敏喘具有成本效益,SCIT特别有效.
- 发现AIT对儿童过敏性鼻炎具有成本效益,SCIT显示成本效益高于SLIT.
- 研究表明,AIT减少了药物使用和恶化,有助于其有利的经济形象.
结论:
- 与SOC相比,过敏原免疫疗法在治疗过敏性鼻炎和喘方面表现出具有成本效益.
- AIT的成本效益可能被低估了,因为许多研究没有充分考虑长期的益处或预防作用.
- 在过敏管理方面,AIT代表了一种有价值的治疗选择,具有显著的经济优势.
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