乳腺癌男性患者的临床病理学特征和预后
Meiling Huang1, Jingjing Xiao1, Changjiao Yan1
1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, The Air Force Medical University, Xi'an, China.
American journal of men's health
|October 4, 2024
概括
男性乳腺癌 (MBC) 发病率正在上升,老年患者受到影响. 关键的生存因素包括年龄,雌激素受体状态,分子类型,P63和内分泌疗法,指导治疗策略.
科学领域:
- 在瘤学瘤学.
- 男人的健康 男人的健康
- 癌症研究 癌症研究
背景情况:
- 男性乳腺癌 (MBC) 是一种罕见的疾病,通常使用类似于女性乳腺癌 (FBC) 的策略来管理.
- 了解MBC独特的临床病理特征和治疗结果对于改善患者护理至关重要.
研究的目的:
- 追溯分析男性乳腺癌患者的临床病理学特征,治疗方法和生存结果.
- 确定影响中国人口中男性乳腺癌患者生存的因素.
主要方法:
- 从2006年8月到2024年3月,对66名在西京医院接受治疗的男性乳腺癌患者进行了回顾性分析.
- 从医院记录和医院的乳腺癌数据库收集数据.
- 对临床病理特征,治疗干预措施 (手术,化疗,内分泌疗法,放射治疗) 和生存数据的统计分析.
主要成果:
- 从2018年开始,MBC发病率呈上升趋势,受影响的个体年龄大于患有FBC的个体.
- 具有阳性激素受体状态的侵入性癌是最常见的组织学类型.
- 在93.9%的患者中进行了修改后的激进乳房切除术;化学疗法,内分泌疗法和放射治疗分别用于59.1%,21.2%和13.6%.
- 平均整体存活期为46.7个月,87.9%的患者在最新的随访时还活着.
- 与生存相关的重要因素包括年龄,雌激素受体状态,分子类型,P63表达和接受内分泌治疗.
结论:
- 这项研究突出了中国男性乳腺癌的关键临床病理特征和治疗模式.
- 年龄,雌激素受体状况,分子亚型,P63和内分泌治疗是MBC的显著预后因素.
- 这些发现为标准化MBC治疗和改善患者治疗结果提供了参考.
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