一个现实的方法来评估干燥表面暴露场景的抗微生物表面
Yi Enn Cheong1, Ralph Weyandt2, Wilma Dewald1
1Volkswagen AG, Group Innovation, Wolfsburg, Germany.
Applied and environmental microbiology
|October 4, 2024
概括
标准抗微生物表面试验不反映现实条件,导致过高估计的疗效. 一种新的干接触测试方法揭示了许多表面的效果不如以前想象的,突出了修订测试标准的必要性.
科学领域:
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
- 传染病控制和控制传染病
背景情况:
- 随着COVID-19的流行,对抗微生物表面的需求增加了,特别是在运输领域.
- 目前的标准测试 (ISO,ASTM,JIS) 使用不切实际的条件 (液体浸泡,37°C,24小时) 干燥表面应用.
- 这些情况可能会在现实环境中高估抗微生物药物的有效性.
研究的目的:
- 开发和验证一种针对抗微生物表面的修改测试方法,更好地模拟现实世界干接触条件.
- 准确评估用于高接触区域的表面的抗菌活性.
主要方法:
- 开发了一种修改后的干燥暴露测试,使用脱离离子水用于注射剂,干燥的小注射剂,环境条件和4小时的接触期.
- 20个抗微生物表面样本使用修改后的方法进行了重新评估.
- 每个样本的细菌物种有效性都被评估.
主要成果:
- 在20个样本中,只有2个样本显示对所有测试的细菌物种有效.
- 8个样本显示对特定物种的部分有效性.
- 在经过修改的试验条件下,10个样本没有显著的抗菌作用.
结论:
- 对于抗微生物表面的现有标准测试方法对于干接触应用是不够的.
- 经过修订,基于现实世界的场景的测试方法对于准确的疗效评估至关重要.
- 许多商用抗微生物表面在实际使用中可能无法达到预期的性能.
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